Search on: RECOMBINANT HUMAN TSH 
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Descriptor English:   Thyrotropin Alfa 
Descriptor Spanish:   Tirotropina Alfa 
Descriptor Portuguese:   Tirotropina Alfa 
Synonyms English:   Alfa, Thyrotropin
Human TSH, Recombinant
Recombinant Human TSH
TSH, Recombinant Human
Thyrogen
rhTSH  
Tree Number:   D06.472.699.631.525.883.374
Definition English:   A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone. 
History Note English:   2010 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   53578 
Unique Identifier:   D057073 

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